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ANTITUMOR EFFECT OF SNAKE VENOMS J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Inflammation; Venom; Snakes; Crotalus durissus terrificus; Bothrops jararaca.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000200002
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EFFECT OF Crotalus durissus terrificus (LAURENTI, 1768) VENOM ON THE EVOLUTION OF EHRLICH ASCITES TUMOR J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The effect of Crotalus durissus terrificus (LAURENTI, 1768) venom on the evolution of Ehrlich ascites tumor cells was evaluated. Thus, 30-day-old male mice of the Swiss strain were inoculated intraperitoneally with 1x10<img SRC="http:/img/fbpe/jvat/v3n2/image1947.gif"> tumor cells. Then, 7 groups of animals were formed: 3 control groups (physiological, venom and tumor) and 4 experimental groups that received different doses of venom. The experimental groups received 5 intraperitoneal venom injections on the 1<img SRC="http:/img/fbpe/jvat/v3n2/image1948.gif"> , 4<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 7<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 10<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Inflammation; Tumor growth; Crotalus durissus terrificus.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200008
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